PPAP2B antibody

Catalog No. ABIN2764066

Product Details anti-PPAP2B Antibody

Target: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAP2B antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: PAP2B,Vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), was originally identified in a functional assay of angiogenesis. VCIP/PAP2b exhibits an ArgGlyAsp (RGD) cell adhesion sequence. Immunoprecipitation and fluorescence-activated cell sorting analyses demonstrated that VCIP-RGD is exposed to the outside of the cell surface. Retroviral transduction of VCIP can induce cell aggregation and cell cell interactions, modestly increase p120 catenin expression and promote activation of the Fak, Akt and GSK3 protein kinases. Expression of VCIP promoted adhesion, spreading and tyrosine phosphorylation of Fak, Shc, Cas and paxillin in endothelial cells. PAP2b/VCIP is expressed in close proximity to vascular endothelial growth factor, von Willebrand factor and {alpha}v3 integrin in tumor vasculatures.

Purification: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from the phosphatidic acid phosphatase 2B protein

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (see vial for dilution) and EIA. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for PPAP2B

Target: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Alternative Name: Phosphatidic Acid Phosphatase 2B (PPAP2B Products)

Synonyms: Dri42 antibody, LPP3 antibody, PAP2B antibody, VCIP antibody, 1110003O22Rik antibody, 2610002D05Rik antibody, AV025606 antibody, D4Bwg0538e antibody, D4Bwg1535e antibody, Lpp3 antibody, Ppab2b antibody, dri42 antibody, lpp3 antibody, pap2b antibody, ppap2bb antibody, vcip antibody, ppap2b antibody, ppap2ba antibody, PPAP2B antibody, si:dkey-19f4.1 antibody, phospholipid phosphatase 3 antibody, phospholipid phosphatase 3 L homeolog antibody, phospholipid phosphatase 3 S homeolog antibody, PLPP3 antibody, Plpp3 antibody, plpp3.L antibody, plpp3.S antibody, plpp3 antibody

UniProt: O14495