SGPP2 antibody

Catalog No. ABIN2764173

Product Details anti-SGPP2 Antibody

Target: SGPP2 (Sphingosine-1-Phosphate Phosphatase 2 (SGPP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGPP2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Characteristics: Sphingosine 1-Phosphate Phosphohydrolase,Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/G-protein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family which play a role in attenuating intracellular S1P signaling.

Purification: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 2 protein.

Application Details

Application Notes: Antibody can be used for Western blotting (1:400 dilution). Tissue lysate should be used at 10-50 μg/lane. Other applications not yet tested. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as whole antiserum

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for SGPP2

Target: SGPP2 (Sphingosine-1-Phosphate Phosphatase 2 (SGPP2))

Alternative Name: Sphingosine 1-Phosphate Phosphatase 2 (SGPP2 Products)

Synonyms: SPP2 antibody, RGD1565739 antibody, SPPase2 antibody, Spp2 antibody, sphingosine-1-phosphate phosphatase 2 antibody, sphingosine-1-phosphate phosphotase 2 antibody, SGPP2 antibody, Sgpp2 antibody

UniProt: Q8IWX5