ACE2 antibody (Middle Region)
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- Target See all ACE2 Antibodies
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Rat, Pig, Dog, Cow, Guinea Pig, Horse, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ACE2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- FVTAPKNVSD IIPRTEVEKA IRMSRSRIND AFRLNDNSLE FLGIQPTLGP
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 86%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against ACE2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human ACE2
- Top Product
- Discover our top product ACE2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 805 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 9, pp. 1434-43, (2015) (PubMed).
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ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 9, pp. 1434-43, (2015) (PubMed).
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- Target
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
- Alternative Name
- ACE2 (ACE2 Products)
- Synonyms
- ACE1 antibody, CD143 antibody, DCP antibody, DCP1 antibody, ICH antibody, MVCD3 antibody, ACEH antibody, 2010305L05Rik antibody, zgc:92514 antibody, angiotensin I converting enzyme antibody, angiotensin I converting enzyme 2 antibody, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 antibody, ACE antibody, ACE2 antibody, Ace2 antibody, ace2 antibody
- Background
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ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This protein catalyzes the cleavage of angiotensin I into angiotensin 1-9. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ACEH, DKFZP434A014
Protein Interaction Partner: ACE2, AGT, CALM1, NTS, GHRL,
Protein Size: 805 - Molecular Weight
- 89 kDa
- Gene ID
- 59272
- NCBI Accession
- NM_021804, NP_068576
- UniProt
- Q9BYF1
- Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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