APH1B antibody (C-Term)
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- Target See all APH1B (Aph1b) Antibodies
- APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))
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Binding Specificity
- C-Term
- Reactivity
- Mouse, Human, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APH1B antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- YYGINLASAF IILVLMGTWA FLAAGGSCRS LKLCLLCQDK NFLLYNQRSR
- Predicted Reactivity
- Cow: 77%, Dog: 85%, Guinea Pig: 92%, Horse: 77%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 92%
- Characteristics
- This is a rabbit polyclonal antibody against APH1B. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product Aph1b Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 216 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))
- Alternative Name
- APH1B (Aph1b Products)
- Synonyms
- APH-1B antibody, PRO1328 antibody, PSFL antibody, TAAV688 antibody, APH-1B' antibody, 2310057K14Rik antibody, Aph1c antibody, aph-1 homolog B, gamma-secretase subunit antibody, aph-1 homolog B, gamma secretase subunit antibody, aph1 homolog B, gamma secretase subunit antibody, APH1B antibody, Aph1b antibody
- Background
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This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
Alias Symbols: APH-1B, DKFZp564D0372, FLJ33115, PRO1328, PSFL, TAAV688
Protein Interaction Partner: UBC, PSENEN, NCSTN, PSEN2, PSEN1,
Protein Size: 216 - Molecular Weight
- 23 kDa
- Gene ID
- 83464
- NCBI Accession
- NM_001145646, NP_001139118
- UniProt
- Q564N3
- Pathways
- Notch Signaling, Neurotrophin Signaling Pathway
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