NFKBIZ antibody (C-Term)

Catalog No. ABIN2774196

The Rabbit Polyclonal anti-NFKBIZ antibody is suitable to detect NFKBIZ in samples from Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Goat, Guinea Pig, Sheep and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for NFKBIZ antibody (C-Term) (ABIN2774196)

Target: NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Goat, Guinea Pig, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKBIZ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NFKBIZ Antibody

Binding Specificity: C-Term

Sequence: VRLLMRKGAD PSTRNLENEQ PVHLVPDGPV GEQIRRILKG KSIQQRAPPY

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against Nfkbiz. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 728 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NFKBIZ

Target: NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))

Alternative Name: Nfkbiz

Background: Nfkbiz is involved in regulation of NF-kappa-B transcription factor complexes. It inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. It inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. It seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50, Nfkbiz has transcriptional activation activity and, together with NFKB1/p50 and RELA, Nfkbiz is recruited to LCN2 promoters.
Alias Symbols: AA408868, INAP, Mail
Protein Interaction Partner: Nfkb2, Nfkb1, Ikbkg, Elf5, Ehf, Il6,
Protein Size: 728

Molecular Weight: 80 kDa

Gene ID: 80859

NCBI Accession: NM_030612, NP_085115

UniProt: Q9EST8

Pathways: NF-kappaB Signaling