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KCNA1 antibody (Middle Region)

KCNA1 Reactivity: Human, Mouse, Rat, Pig, Dog, Horse, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776084
  • Target See all KCNA1 Antibodies
    KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))
    Binding Specificity
    • 15
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 74
    • 22
    • 16
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Pig, Dog, Horse, Guinea Pig
    Host
    • 72
    • 7
    Rabbit
    Clonality
    • 73
    • 6
    Polyclonal
    Conjugate
    • 32
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KCNA1 antibody is un-conjugated
    Application
    • 54
    • 30
    • 21
    • 13
    • 13
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    ISIVIFCLET LPELKDDKDF TGTVHRIDNT TVIYNSNIFT DPFFIVETLC
    Predicted Reactivity
    Dog: 100%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against KCNA1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human KCNA1
    Top Product
    Discover our top product KCNA1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 495 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Glasscock, Voigt, McCauley, Sun, Li, Chiang, Zhou, Molina, Thomas, Schmidt, Skapura, Noebels, Dobrev, Wehrens: "Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation." in: Basic research in cardiology, Vol. 110, Issue 5, pp. 505, (2015) (PubMed).

    Tan, Lennon, Klein, Boeve, Pittock: "Clinical spectrum of voltage-gated potassium channel autoimmunity." in: Neurology, Vol. 70, Issue 20, pp. 1883-90, (2008) (PubMed).

  • Target
    KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))
    Alternative Name
    KCNA1 (KCNA1 Products)
    Synonyms
    AEMK antibody, EA1 antibody, HBK1 antibody, HUK1 antibody, KV1.1 antibody, MBK1 antibody, MK1 antibody, RBK1 antibody, KCNA1 antibody, AI840627 antibody, Kca1-1 antibody, Kv1.1 antibody, Mk-1 antibody, Shak antibody, mceph antibody, Kcna antibody, Kcpvd antibody, potassium voltage-gated channel subfamily A member 1 antibody, potassium voltage-gated channel, shaker-related subfamily, member 1 antibody, fragile site, aphidicolin type, common, fra(12)(q24) antibody, KCNA1 antibody, Kcna1 antibody, FRA12E antibody
    Background
    KCNA1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene. This transcript is supported by sequences from mouse. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MGC126782, MGC138385, MK1, RBK1
    Protein Interaction Partner: KCNRG, KCNE4, DLG4, DLG1, KCNA4, KCNA3, KCNA2, RTN4, CNTNAP1,
    Protein Size: 495
    Molecular Weight
    56 kDa
    Gene ID
    3736
    NCBI Accession
    NM_000217, NP_000208
    UniProt
    Q09470
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