KCNA1 antibody (Middle Region)

Catalog No. ABIN2776084

The Rabbit Polyclonal anti-KCNA1 antibody has been validated for WB. It is suitable to detect KCNA1 in samples from Human, Rat, Mouse, Dog, Pig, Horse and Guinea Pig. There are 2+ publications available.

Quick Overview for KCNA1 antibody (Middle Region) (ABIN2776084)

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Reactivity: Human, Rat, Mouse, Dog, Pig, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNA1 Antibody

Binding Specificity: Middle Region

Sequence: ISIVIFCLET LPELKDDKDF TGTVHRIDNT TVIYNSNIFT DPFFIVETLC

Predicted Reactivity: Dog: 100%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against KCNA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCNA1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 495 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-KCNA1 antibody (ABIN2776084)

Glasscock, Voigt, McCauley, Sun, Li, Chiang, Zhou, Molina, Thomas, Schmidt, Skapura, Noebels, Dobrev, Wehrens: "Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation." in: Basic research in cardiology, Vol. 110, Issue 5, pp. 505, (2015) (PubMed).

Tan, Lennon, Klein, Boeve, Pittock: "Clinical spectrum of voltage-gated potassium channel autoimmunity." in: Neurology, Vol. 70, Issue 20, pp. 1883-90, (2008) (PubMed).

Target Details for KCNA1

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Alternative Name: KCNA1

Background: KCNA1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene. This transcript is supported by sequences from mouse. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MGC126782, MGC138385, MK1, RBK1
Protein Interaction Partner: KCNRG, KCNE4, DLG4, DLG1, KCNA4, KCNA3, KCNA2, RTN4, CNTNAP1,
Protein Size: 495

Molecular Weight: 56 kDa

Gene ID: 3736

NCBI Accession: NM_000217, NP_000208

UniProt: Q09470