KCNN1 antibody (C-Term)

Catalog No. ABIN2776145

Product Details anti-KCNN1 Antibody

Target: KCNN1 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Guinea Pig, Cow, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNN1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KIEQGKLNDQ ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 79%, Horse: 92%, Human: 100%, Pig: 93%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against KCNN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 543 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-KCNN1 antibody (ABIN2776145)

Arnold, Mühlen: "The influence of the thickness of non-piezoelectric pieces on pre-stressed piezotransducers." in: Ultrasonics, Vol. 41, Issue 3, pp. 191-6, (2003) (PubMed).

Target Details for KCNN1

Target: KCNN1 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1 (KCNN1))

Alternative Name: KCNN1 (KCNN1 Products)

Background: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels.
Alias Symbols: SK1, hSK1, SKCA1, KCa2.1
Protein Interaction Partner: UBC,
Protein Size: 543

Molecular Weight: 60 kDa

Gene ID: 3780

NCBI Accession: NM_002248, NP_002239

UniProt: Q6DJU4