SCN7A antibody (N-Term)

Catalog No. ABIN2776152

Product Details anti-SCN7A Antibody

Target: SCN7A (Sodium Channel, Voltage-Gated, Type VII, alpha Subunit (SCN7A))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN7A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PFIYGNLSQG MVSEPLEDVD PYYYKKKNTF IVLNKNRTIF RFNAASILCT

Predicted Reactivity: Dog: 79%, Guinea Pig: 80%, Human: 100%, Mouse: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SCN7A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human SCN7A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SCN7A

Target: SCN7A (Sodium Channel, Voltage-Gated, Type VII, alpha Subunit (SCN7A))

Alternative Name: SCN7A (SCN7A Products)

Synonyms: 1110034K09Rik antibody, AI642000 antibody, NaG antibody, Nav2 antibody, Nav2.3 antibody, Nax antibody, Scn6a antibody, Na-G antibody, Nav2.1 antibody, Nav2.2 antibody, SCN6A antibody, sodium channel, voltage-gated, type VII, alpha antibody, sodium voltage-gated channel alpha subunit 7 antibody, Scn7a antibody, SCN7A antibody

Background: This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics, the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels, domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown.
Alias Symbols: NaG, SCN6A, Nav2.1, Nav2.2
Protein Size: 762

Molecular Weight: 83 kDa

Gene ID: 6332

NCBI Accession: NM_002976, NP_002967

UniProt: Q01118