SMPD1 antibody (Middle Region)

Catalog No. ABIN2776372

Product Details anti-SMPD1 Antibody

Target: SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Sheep, Rabbit, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RLRDVFGWGN LTCPICKGLF TAINLGLKKE PNVARVGSVA IKLCNLLKIA

Predicted Reactivity: Cow: 83%, Dog: 87%, Guinea Pig: 87%, Horse: 80%, Human: 100%, Mouse: 80%, Rabbit: 87%, Rat: 87%, Sheep: 83%

Characteristics: This is a rabbit polyclonal antibody against SMPD1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SMPD1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMPD1

Target: SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))

Alternative Name: SMPD1 (SMPD1 Products)

Synonyms: ASM antibody, ASMASE antibody, NPD antibody, A-SMase antibody, Zn-SMase antibody, aSMase antibody, SMPD1 antibody, sphingomyelin phosphodiesterase 1 antibody, sphingomyelin phosphodiesterase 1, acid lysosomal antibody, sphingomyelin phosphodiesterase antibody, SMPD1 antibody, Smpd1 antibody, LOC5578088 antibody

Background: The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.
Alias Symbols: ASM, NPD, ASMASE
Protein Size: 171

Molecular Weight: 18 kDa

Gene ID: 6609

NCBI Accession: NM_000543, NP_000534

UniProt: P17405