DCP2 antibody (C-Term)

Catalog No. ABIN2776652

Product Details anti-DCP2 Antibody

Target: DCP2 (DCP2 Decapping Enzyme Homolog (DCP2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Horse, Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCP2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VEKLSRTKFR HSQQLFPDGS PGDQWVKHRQ PLQQKPYNNH SEMSDLLKGK

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against DCP2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DCP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 420 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DCP2

Target: DCP2 (DCP2 Decapping Enzyme Homolog (DCP2))

Alternative Name: DCP2 (DCP2 Products)

Synonyms: DDBDRAFT_0185453 antibody, DDBDRAFT_0252811 antibody, DDB_0185453 antibody, DDB_0252811 antibody, 2410015D23Rik antibody, 5730537H01Rik antibody, AL118268 antibody, NUDT20 antibody, RGD1562909 antibody, mRNA-decapping enzyme 2 antibody, hypothetical protein antibody, decapping mRNA 2 antibody, CpipJ_CPIJ019463 antibody, PTRG_05936 antibody, dcp2 antibody, MCYG_05106 antibody, MGYG_07617 antibody, PGTG_03310 antibody, Tsp_04018 antibody, DCP2 antibody, Dcp2 antibody

Background: DCP2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a poly(A) tail, but has no activity towards a cap structure lacking a RNA moiety.DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-539 AY135173.1 1-539 540-1992 AK090564.1 481-1933 1993-8947 AC008536.7 154323-161277
Alias Symbols: FLJ33245, NUDT20
Protein Interaction Partner: FAM96B, DCP1A, UBC, EDC4, DCP1B, SFXN2, ANGEL2, ARMCX5, DARS2, ELP3, QPCTL, GTPBP2, TRMT2A, FBXO3, INTS7, POLD3, GFPT2, AP1M1, SQSTM1, IKBKAP, TRRAP, TARS, ABCE1, PHKB, PGM3, PFKM, IDE, GLUD1, GGT7, GGCX, GFPT1, GARS, FANCD2, EIF5A, SLC25A10, CAPN2, NAGK,
Protein Size: 420

Molecular Weight: 48 kDa

Gene ID: 167227

NCBI Accession: NM_152624, NP_689837

UniProt: Q8IU60