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PPARG antibody (N-Term)

PPARG Reactivity: Human, Dog, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777644
  • Target See all PPARG Antibodies
    PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
    Binding Specificity
    • 21
    • 18
    • 16
    • 16
    • 16
    • 14
    • 9
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 157
    • 109
    • 96
    • 34
    • 33
    • 24
    • 22
    • 20
    • 15
    • 10
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Dog, Pig
    Host
    • 149
    • 18
    • 3
    • 2
    Rabbit
    Clonality
    • 153
    • 20
    Polyclonal
    Conjugate
    • 86
    • 14
    • 11
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    This PPARG antibody is un-conjugated
    Application
    • 155
    • 60
    • 55
    • 52
    • 52
    • 31
    • 22
    • 16
    • 14
    • 13
    • 7
    • 5
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL
    Predicted Reactivity
    Dog: 92%, Human: 100%, Pig: 85%
    Characteristics
    This is a rabbit polyclonal antibody against PPARG. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PPARG
    Top Product
    Discover our top product PPARG Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 505 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
    Alternative Name
    PPARG (PPARG Products)
    Synonyms
    PPAR gamma antibody, PPARg2 antibody, PPARG antibody, Nr1c3 antibody, PPAR-gamma antibody, PPAR-gamma2 antibody, PPARgamma antibody, PPARgamma2 antibody, NR1C3 antibody, CIMT1 antibody, GLM1 antibody, PPARG1 antibody, PPARG2 antibody, xPPAR-gamma antibody, PPAR-GAMMA antibody, PPARGAMMA antibody, peroxisome proliferator-activated receptor gamma antibody, peroxisome proliferator activated receptor gamma antibody, peroxisome proliferator activated receptor gamma L homeolog antibody, PPARG antibody, Pparg antibody, pparg.L antibody
    Background
    PPARG is a receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPARG is the key regulator of adipocyte differentiation and glucose homeostasis.This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
    Alias Symbols: NR1C3, PPARG1, PPARG2, GLM1, CIMT1, PPARgamma
    Protein Interaction Partner: HDAC3, NCOA1, NCOA3, SUMO1, UBC, SUMO2, RXRA, MED1, HMGA1, EP300, NCOA2, CDC34, PRKAA2, PRKAA1, PPARGC1A, ASH2L, RBBP5, NSD1, NCOA6, PAXIP1, MUC1, NR3C1, SMAD2, CREBBP, ALOX15B, ZFYVE9, USP7, NCOR1, CDK5, SMARCD3, SMARCA4, NEDD4, BCAS2, MIF4GD, MED14, JAZ
    Protein Size: 505
    Molecular Weight
    57 kDa
    Gene ID
    5468
    NCBI Accession
    NM_015869, NP_056953
    UniProt
    P37231
    Pathways
    MAPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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