BCL11B antibody (Middle Region)

Catalog No. ABIN2777845

Product Details anti-BCL11B Antibody

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL11B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: QASKLKRHMK THMHKAGSLA GRSDDGLSAA SSPEPGTSEL AGEGLKAADG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against BCL11B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BCL11B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 823 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BCL11B

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Alternative Name: BCL11B (BCL11B Products)

Synonyms: BCL11B antibody, 9130430L19Rik antibody, AI604821 antibody, B630002E05Rik antibody, BCL-11B antibody, Ctip2 antibody, Rit1 antibody, ATL1 antibody, ATL1-alpha antibody, ATL1-beta antibody, ATL1-delta antibody, ATL1-gamma antibody, CTIP-2 antibody, CTIP2 antibody, RIT1 antibody, ZNF856B antibody, hRIT1-alpha antibody, B-cell CLL/lymphoma 11B antibody, B cell leukemia/lymphoma 11B antibody, B-cell CLL/lymphoma 11B (zinc finger protein) antibody, BCL11B antibody, Bcl11b antibody

Background: BCL11B is the tumor-suppressor protein involved in T-cell lymphomas. BCL11B may function on the P53-signaling pathway. BCL11B may be a key regulator of both differentiation and survival during thymocyte development. BCL11B repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Alias Symbols: CTIP-2, CTIP2, RIT1, hRIT1-alpha, ZNF856B
Protein Interaction Partner: HDAC6, HDAC2, HDAC1, NOTCH1, UBC, HDAC3, SUV39H1, tat, CBX5, NR2F1, SP1, MBD3, MTA2, MTA1, RBBP7, RBBP4, CHD4, NR2F2,
Protein Size: 823

Molecular Weight: 88 kDa

Gene ID: 64919

NCBI Accession: NM_022898, NP_075049