SIM1 antibody (Middle Region)

Catalog No. ABIN2777847

Product Details anti-SIM1 Antibody

Target: SIM1 (Single-Minded Homolog 1 (SIM1))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Mouse, Rat, Dog, Horse, Rabbit, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIM1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Sequence: SSSKSKSRTS PYPQYSGFHT ERSESDHDSQ WGGSPLTDTA SPQLLDPADR

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SIM1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SIM1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 766 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIM1

Target: SIM1 (Single-Minded Homolog 1 (SIM1))

Alternative Name: SIM1 (SIM1 Products)

Synonyms: bHLHe14 antibody, mSIM1 antibody, single-minded family bHLH transcription factor 1 antibody, single-minded homolog 1 (Drosophila) antibody, single-minded family bHLH transcription factor 1a antibody, SIM1 antibody, Sim1 antibody, sim1a antibody

Background: SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.
Alias Symbols: bHLHe14
Protein Interaction Partner: ARNT, HSP90AA1,
Protein Size: 766

Molecular Weight: 85 kDa

Gene ID: 6492

NCBI Accession: NM_005068, NP_005059

UniProt: P81133