CBFA2T3 antibody (N-Term)

Catalog No. ABIN2778220

Product Details anti-CBFA2T3 Antibody

Target: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFA2T3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QPRSTPPSMP PPPPAASQGA TRPPSFTPHT LMNGSSHSPT AINGAPCTPN

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 85%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CBFA2T3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CBFA2T3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 567 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CBFA2T3

Target: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Alternative Name: CBFA2T3 (CBFA2T3 Products)

Synonyms: A630044F12Rik antibody, AI465270 antibody, AW229127 antibody, Cbfa2t3h antibody, ETO-2 antibody, Eto2 antibody, MTGR2 antibody, MTG16a antibody, MTG16b antibody, ETO2 antibody, MTG16 antibody, ZMYND4 antibody, core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) antibody, CBFA2/RUNX1 translocation partner 3 antibody, Cbfa2t3 antibody, CBFA2T3 antibody

Background: The t(16,21)(q24,q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of CBFA2T3. In addition, CBFA2T3 is a putative breast tumor suppressor.
Alias Symbols: ETO2, MTG16, MTGR2, ZMYND4
Protein Interaction Partner: Zbtb38, Zbtb4, ZBTB33, GMEB2, SEC24A, MATN2, ZBTB47, UBC, RUNX1, TAL1, TRIM33, SIN3B, NCOR1, HDAC3, CBFA2T3, CBFA2T2, HDAC1, PRKAR2A, RUNX1T1, LDB1, TCF3, HDAC8, HDAC6, HDAC2,
Protein Size: 567

Molecular Weight: 62 kDa

Gene ID: 863

NCBI Accession: NM_175931, NP_787127

UniProt: O75082