TCF7L2 antibody (N-Term)

Catalog No. ABIN2778365

Product Details anti-TCF7L2 Antibody

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF7L2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN

Predicted Reactivity: Cow: 100%, Dog: 75%, Guinea Pig: 75%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Tcf7l2. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 459 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TCF7L2

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Alternative Name: Tcf7l2 (TCF7L2 Products)

Synonyms: TCF4B antibody, TCF4E antibody, Tcf-4 antibody, Tcf4 antibody, mTcf-4B antibody, mTcf-4E antibody, tcf4 antibody, XTCF-4 antibody, tcf4e antibody, TCF4 antibody, TCF-4 antibody, TCFL2 antibody, transcription factor 7 like 2 antibody, transcription factor 7-like 2 antibody, transcription factor 7 like 2, T cell specific, HMG box antibody, transcription factor 7 like 2 L homeolog antibody, transcription factor 7-like 2 (T-cell specific, HMG-box) antibody, TCF7L2 antibody, LOC100545943 antibody, Tcf7l2 antibody, tcf7l2 antibody, tcf7l2.L antibody

Background: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
Alias Symbols: TCF4, TCF-4
Protein Interaction Partner: Ctnnb1, Hdac1, Hdac2, Hnf4a,
Protein Size: 619

Molecular Weight: 68 kDa

Gene ID: 6934

NCBI Accession: XM_005270084, XP_005270141

UniProt: Q9NQB0

Pathways: WNT Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus