PSMA1 antibody (C-Term)

Catalog No. ABIN2778810

Product Details anti-PSMA1 Antibody

Target: PSMA1 (Proteasome Subunit alpha Type 1 (PSMA1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: TYLERHMSEF MECNLNELVK HGLRALRETL PAEQDLTTKN VSIGIVGKDL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PSMA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSMA1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 263 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PSMA1 antibody (ABIN2778810)

Cron, Zhu, Kushwaha, Hsieh, Merzon, Rameseder, Chen, DAndrea, Kozono: "Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer." in: PLoS ONE, Vol. 8, Issue 9, pp. e73710, (2013) (PubMed).

Target Details for PSMA1

Target: PSMA1 (Proteasome Subunit alpha Type 1 (PSMA1))

Alternative Name: PSMA1 (PSMA1 Products)

Synonyms: PSMA1 antibody, pros30 antibody, DDBDRAFT_0204226 antibody, DDBDRAFT_0214956 antibody, DDB_0204226 antibody, DDB_0214956 antibody, C2 antibody, HC2 antibody, Pros-30 antibody, alpha-type antibody, NU antibody, PROS30 antibody, CC2 antibody, zgc:92726 antibody, 143314_at antibody, Alpha-6 antibody, CG4904 antibody, Dmel\CG4904 antibody, PROS-35 antibody, PROS-Dm35 antibody, Pros-35 antibody, Pros-Dm35 antibody, Prosalpha6 antibody, alpha6 antibody, alpha_dm antibody, anon-SAGE:Wang-116 antibody, pros 35 antibody, pros35 antibody, proteasome subunit alpha 1 antibody, proteasome subunit alpha type 1 antibody, 20S proteasome subunit C2 antibody, proteasome (prosome, macropain) subunit, alpha type 1 antibody, proteasome subunit alpha 1 L homeolog antibody, Proteasome alpha6 subunit antibody, PSMA1 antibody, psma1 antibody, CNB05540 antibody, psmA1 antibody, Psma1 antibody, psma1.L antibody, Prosalpha6 antibody

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA1 is a member of the peptidase T1A family which is a 20S core alpha subunit.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
Alias Symbols: HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30
Protein Interaction Partner: PRDM14, CEP70, CCDC102B, GNPTAB, CEP72, KCTD9, ROPN1, ABI3, SH3GLB1, APIP, LDOC1, MTUS2, MAPRE3, MAPRE1, IKZF3, MID2, EHMT2, PNMA2, IKZF1, TRIM10, HUWE1, HOMER3, PNMA1, KRT38, BLZF1, MAD1L1, MKRN3, REL, PSMA3, MLH1, KRT31, KRT15, KRTAP5-9, GOLGA2, CDA, CC
Protein Size: 263

Molecular Weight: 29 kDa

Gene ID: 5682

NCBI Accession: NM_002786, NP_002777

UniProt: P25786

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA