PSMA6 antibody (N-Term)

Catalog No. ABIN2778812

Product Details anti-PSMA6 Antibody

Target: PSMA6 (Proteasome Subunit alpha 6 (PSMA6))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Goat, Guinea Pig, Horse, Sheep, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMA6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EYAFKAINQG GLTSVAVRGK DCAVIVTQKK VPDKLLDSST VTHLFKITEN

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PSMA6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PSMA6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 246 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMA6

Target: PSMA6 (Proteasome Subunit alpha 6 (PSMA6))

Alternative Name: PSMA6 (PSMA6 Products)

Synonyms: IOTA antibody, PROS27 antibody, p27K antibody, psma6 antibody, psma6b antibody, zgc:91778 antibody, proteasome subunit alpha 6 antibody, proteasome (prosome, macropain) subunit, alpha type 6 antibody, proteasome subunit alpha 6a antibody, proteasome subunit alpha 6 L homeolog antibody, proteasome subunit alpha 6, like antibody, PSMA6 antibody, Psma6 antibody, psma6a antibody, psma6.L antibody, psma6l antibody

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA6 is a member of the peptidase T1A family, which is a 20S core alpha subunit.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IOTA, MGC22756, MGC2333, MGC23846, PROS27, p27K
Protein Interaction Partner: UBC, RNF170, LIMD2, C19orf57, TRIM39, ZBTB44, CADM1, HUWE1, PSMA3, RTP5, KRTAP4-2, AURKA, PSMD14, MDM2, PSMA5, PSMG3, PSMG2, PSMG1, RNF2, PSMB8, PSMB7, PSMB6, PSMB5, PSMB4, PSMB3, PSMB2, PSMB1, PSMA7, PSMA4, PSMA1, HNRNPA2B1, PYCRL, RPP38, RPP30, CAST, PS
Protein Size: 246

Molecular Weight: 27 kDa

Gene ID: 5687

NCBI Accession: NM_002791, NP_002782

UniProt: P60900

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA