KHDRBS1 antibody (N-Term)

Catalog No. ABIN2778999

This Rabbit Polyclonal antibody specifically detects KHDRBS1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Dog and Horse.

Quick Overview for KHDRBS1 antibody (N-Term) (ABIN2778999)

Target: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KHDRBS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-KHDRBS1 Antibody

Binding Specificity: N-Term

Sequence: LPELMAEKDS LDPSFTHAMQ LLTAEIEKIQ KGDSKKDDEE NYLDLFSHKN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against KHDRBS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KHDRBS1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 443 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KHDRBS1

Target: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Alternative Name: KHDRBS1

Background: KHDRBS1 recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, KHDRBS1 functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. KHDRBS1 play a role in G2-M progression in the cell cycle. It represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. KHDRBS1 also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.
Alias Symbols: FLJ34027, Sam68, p62, p68
Protein Interaction Partner: UBC, LGR4, DROSHA, RPA3, RPA2, RPA1, RNF2, EZH2, BMI1, SUZ12, rev, APBB1, GAS7, WBP4, RASA1, SRC, CSK, PLCG1, PIK3R1, IRS1, CD81, TNFRSF1A, KHDRBS3, GPHN, RBM7, PIK3R3, HNRNPK, GRB2, EFEMP1, DHX9, DDX5, CRKL, CIRBP, ACTB, AZIN1, RBMX, AGO1, POT1, RBFOX2,
Protein Size: 443

Molecular Weight: 48 kDa

Gene ID: 10657

NCBI Accession: NM_006559, NP_006550

UniProt: Q07666

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy