OAS1 antibody (C-Term)
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- Target See all OAS1 Antibodies
- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This OAS1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- EAWLNYPCFK NWDGSPVSSW ILLAESNSAD DETDDPRRYQ KYGYIGTHEY
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against OAS1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product OAS1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 400 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway." in: Cancer research, Vol. 71, Issue 1, pp. 255-65, (2011) (PubMed).
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Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway." in: Cancer research, Vol. 71, Issue 1, pp. 255-65, (2011) (PubMed).
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- Target
- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
- Alternative Name
- OAS1 (OAS1 Products)
- Synonyms
- OAS1 antibody, IFI-4 antibody, OIAS antibody, OIASI antibody, L3 antibody, Pp2a2 antibody, 2',5'-oligoadenylate synthetase 1 antibody, 2'-5'-oligoadenylate synthetase 1 antibody, 2'-5' oligoadenylate synthetase 1A antibody, protein phosphatase 2 catalytic subunit beta antibody, OAS1 antibody, Oas1a antibody, Ppp2cb antibody, Oas1 antibody
- Background
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OAS1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Mutations in this gene have been associated with host susceptibility to viral infection.
Alias Symbols: IFI-4, OIAS, OIASI
Protein Interaction Partner: EXOC5, TRIM27, ACTN1, PRMT6, WBSCR22, RPL30, HCVgp1,
Protein Size: 400 - Molecular Weight
- 46 kDa
- Gene ID
- 4938
- NCBI Accession
- NM_016816, NP_058132
- UniProt
- P00973
- Pathways
- Hepatitis C
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