UHRF1 antibody (C-Term)

Catalog No. ABIN2779741

Product Details anti-UHRF1 Antibody

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UHRF1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DDEPGPWTKE GKDRIKKLGL TMQYPEGYLE ALANREREKE NSKREEEEQQ

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against UHRF1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human UHRF1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UHRF1

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Alternative Name: UHRF1 (UHRF1 Products)

Synonyms: ICBP90 antibody, Np95 antibody, RNF106 antibody, hNP95 antibody, hUHRF1 antibody, AL022808 antibody, NP95 antibody, fb97f09 antibody, wu:fb97f09 antibody, zgc:63539 antibody, UHRF1 antibody, ubiquitin like with PHD and ring finger domains 1 antibody, ubiquitin-like, containing PHD and RING finger domains, 1 antibody, ubiquitin-like with PHD and ring finger domains 1 antibody, UHRF1 antibody, Uhrf1 antibody, uhrf1 antibody

Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein Interaction Partner: UBC, H3F3B, H3F3A, HIST2H3D, HIST2H3A, HIST2H3C, UHRF1, HIST1H3F, HIST1H3B, HIST1H3E, HIST1H3C, HIST1H3D, HIST1H3A, HIST3H3, DNMT1, PARP1, PARP2, RNF2, USP7, KAT5, MPG, BTRC, CUL1, ZPR1, RB1, PRKACA, PML, SUV39H1, EZH2, SUZ12, UHRF2, USP11, HDAC1, ELAVL1,
Protein Size: 793

Molecular Weight: 90 kDa

Gene ID: 29128

UniProt: Q96T88