RORC antibody (N-Term)

Catalog No. ABIN2779965

Product Details anti-RORC Antibody

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RORC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: VKFGRMSKKQ RDSLHAEVQK QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG

Predicted Reactivity: Dog: 85%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Rorc. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 516 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RORC

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Alternative Name: Rorc (RORC Products)

Synonyms: NR1F3 antibody, RORG antibody, RZR-GAMMA antibody, RZRG antibody, TOR antibody, Nr1f3 antibody, RORgamma antibody, Thor antibody, RAR related orphan receptor C antibody, RAR-related orphan receptor C antibody, RAR-related orphan receptor gamma antibody, RORC antibody, Rorc antibody

Background: Rorc is an orphan nuclear receptor. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.
Alias Symbols: Nr1f3, RORgamma, TOR, Thor
Protein Interaction Partner: Cul3, Chd4, Ewsr1,
Protein Size: 516

Molecular Weight: 58 kDa

Gene ID: 19885

NCBI Accession: NM_011281, NP_035411

UniProt: P51450

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway