NR5A1 antibody (C-Term)
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- Target See all NR5A1 Antibodies
- NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Guinea Pig, Horse, Rabbit, Cow, Sheep
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NR5A1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- VADQMTLLQN CWSELLVLDH IYRQVQYGKE DSILLVTGQE VELSTVAVQA
- Predicted Reactivity
- Cow: 79%, Guinea Pig: 93%, Horse: 86%, Human: 86%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 79%
- Characteristics
- This is a rabbit polyclonal antibody against Nr5a1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Nr5a1
- Top Product
- Discover our top product NR5A1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 462 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))
- Alternative Name
- Nr5a1 (NR5A1 Products)
- Synonyms
- AD4BP antibody, ELP antibody, FTZ1 antibody, FTZF1 antibody, POF7 antibody, SF-1 antibody, SF1 antibody, SPGF8 antibody, SRXY3 antibody, Ad4BP antibody, ELP-3 antibody, Ftz-F1 antibody, Ftzf1 antibody, Ad4BP/SF-1 antibody, Ad4bp antibody, Sf-1 antibody, NR5A1 antibody, sf-1 antibody, elp antibody, sf1 antibody, ftz1 antibody, ad4bp antibody, ftzf1 antibody, SF-1/Ad4BP antibody, SI:zC167P9.2 antibody, ff1d antibody, nr5a2l antibody, nuclear receptor subfamily 5 group A member 1 antibody, nuclear receptor subfamily 5, group A, member 1 antibody, nuclear receptor subfamily 5 group A member 1 L homeolog antibody, nuclear receptor subfamily 6 group A member 1 antibody, nuclear receptor subfamily 5, group A, member 1b antibody, NR5A1 antibody, Nr5a1 antibody, nr5a1.L antibody, nr5a1 antibody, NR6A1 antibody, nr5a1b antibody
- Background
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Nr5a1 is a transcriptional activator. It seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. It binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Nr5a1 also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Nr5a1 binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Nr5a1 is activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Alias Symbols: Ad4BP, ELP, ELP-3, Ftz-F1, Ftzf1, SF-1, SF1
Protein Interaction Partner: Pitx1, Nfya, Pin1, Sumo1, Ubc, Egr1, Mir383, Ncoa1, Sumo2, Ppargc1a, Lhb, Tbx19, Sox9, Nr0b2, Nr0b1, Ncoa2,
Protein Size: 462 - Molecular Weight
- 52 kDa
- Gene ID
- 26423
- NCBI Accession
- NM_139051, NP_620639
- UniProt
- P33242
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Maintenance of Protein Location
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