SCN3B antibody (N-Term)

Catalog No. ABIN2780215

Product Details anti-SCN3B Antibody

Target: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Binding Specificity: N-Term

Reactivity: Rat, Human, Mouse, Cow, Dog, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN3B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RPEGGKDFLI YEYRNGHQEV ESPFQGRLQW NGSKDLQDVS ITVLNVTLND

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SCN3B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SCN3B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 215 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SCN3B antibody (ABIN2780215)

Ho, Zhao, Malinowski, Chahine, OLeary: "Differential expression of sodium channel ? subunits in dorsal root ganglion sensory neurons." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15044-53, (2012) (PubMed).

Hu, Barajas-Martinez, Burashnikov, Springer, Wu, Varro, Pfeiffer, Koopmann, Cordeiro, Guerchicoff, Pollevick, Antzelevitch: "A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype." in: Circulation. Cardiovascular genetics, Vol. 2, Issue 3, pp. 270-8, (2009) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Target Details for SCN3B

Target: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Alternative Name: SCN3B (SCN3B Products)

Synonyms: 1110001K16Rik antibody, 4833414B02Rik antibody, Scnb3 antibody, HSA243396 antibody, SCNB3 antibody, sodium voltage-gated channel beta subunit 3 antibody, sodium channel, voltage-gated, type III, beta antibody, SCN3B antibody, Scn3b antibody

Background: SCN3B is one member of the sodium channel beta subunits of voltage-gated sodium channels, which are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B influences the inactivation kinetics of the sodium channel.
Alias Symbols: HSA243396, SCNB3
Protein Interaction Partner: NFASC,
Protein Size: 215

Molecular Weight: 24 kDa

Gene ID: 55800

NCBI Accession: NM_018400, NP_060870

UniProt: Q9NY72