CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation . Alias Symbols: AI462102, AML1, Cbfa2, Pebp2a2, Pebpa2b Protein Interaction Partner: Kat6a, Ubc, Cbfb, Foxp3, Rbbp4, Gata1, Fli1, Phc1, Cdk6, Cbx3, Bmi1, Pml, Mbd3, Smad2, Prmt1, Hdac2, Hcfc1, Gata2, Hdac1, Wdr5, Mta1, Smarcd1, Pcgf5, Smarcc2, Pold3, Smarce1, Set, Mta2, Ash2l, Tal1, Smarcc1, Smarcb1, Smarca4, Sin3a, Rnf2, Ring1, Cbfa2t3, Protein Size: 387