ZFP36 antibody (Middle Region)

Catalog No. ABIN2780505

Product Details anti-ZFP36 Antibody

Target: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFP36 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against ZFP36. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ZFP36

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 326 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZFP36

Target: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Alternative Name: ZFP36 (ZFP36 Products)

Synonyms: G0S24 antibody, GOS24 antibody, NUP475 antibody, RNF162A antibody, TIS11 antibody, TTP antibody, zfp-36 antibody, c3h-1 antibody, g0s24 antibody, gos24 antibody, nup475 antibody, rnf162a antibody, tis11 antibody, ttp antibody, ZFP36 antibody, C3H-1 antibody, Gos24 antibody, Nup475 antibody, TIS11D antibody, TISII antibody, Tis11 antibody, Ttp antibody, Zfp-36 antibody, ZFP36 ring finger protein antibody, ZFP36 ring finger protein L homeolog antibody, tristetraproline antibody, Tristetraproline antibody, similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth antibody, zinc finger protein 36 antibody, ZFP36 antibody, zfp36.L antibody, EDI_287240 antibody, Bm1_42085 antibody, LOAG_03119 antibody, zfp36 antibody, Zfp36 antibody

Background: ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
Alias Symbols: G0S24, GOS24, NUP475, RNF162A, TIS11, TTP
Protein Interaction Partner: YWHAB, PPP2CA, DNAJB1, DCP1B, DHX36, PRR5L, XRN1, UBC, TRAF2, EXOSC6, UPF2, EXOSC8, YWHAQ, TNF, DCP2, EDC3, DCP1A, EDC4, CDK6, APP, LIN28A, SH3KBP1, PABPC1, NCL, MAP3K4, HSPA4, HDAC7, HDAC3, NFKB1, HOXC9, HDAC1, CCDC85B, MAPKAPK2, YWHAG, SFN, HMGB1, NUP21
Protein Size: 326

Molecular Weight: 34 kDa

Gene ID: 7538

NCBI Accession: NM_003407, NP_003398

UniProt: P26651