Coronin 1a antibody (C-Term)

Catalog No. ABIN2780827

Product Details anti-Coronin 1a Antibody

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coronin 1a antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ELRVNRGLDT GRRRAAPEAS GTPSSDAVSR LEEEMRKLQA TVQELQKRLD

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 77%, Pig: 90%, Rabbit: 79%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against CORO1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CORO1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 461 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Coronin 1a

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Alternative Name: CORO1A (CORO1A Products)

Synonyms: CORO1A antibody, cor1a antibody, Clabp antibody, Lmb3 antibody, TACO antibody, p57 antibody, CLABP antibody, CLIPINA antibody, HCORO1 antibody, fj83g12 antibody, wu:fj83g12 antibody, zgc:63766 antibody, coronin 1A antibody, Coronin-1A antibody, coronin, actin binding protein 1A antibody, coronin, actin binding protein, 1A antibody, CORO1A antibody, cor1a antibody, Coro1a antibody, coro1a antibody

Background: CORO1A is a novel actin-binding protein with a WD repeat and a leucine zipper motif. CORO1A forms homodimers, that the association is mediated by the leucine zipper structure in the C-terminal region, and that it plays a role in the cross-linking of F-actin in the cell. The leukocyte plasma membrane associates with the actin cytoskeleton through CORO1A.Downregulation of CORO1A gene transcription restricts entry/survival of mycobacteria within macrophages
Alias Symbols: p57, TACO, CLABP, HCORO1, CLIPINA
Protein Interaction Partner: FSD2, GOLGA2, UBC, YTHDC1, SPATA20, POT1, TAB1, GIT2, POLR1C, STAT3, SMARCD1, MAGOH, SMAD3, LMO2, FHL3, FMNL1, NCF4, THBS1, ACTB, DKK1, UBE2G2,
Protein Size: 461

Molecular Weight: 51 kDa

Gene ID: 11151

NCBI Accession: NM_007074, NP_009005

UniProt: Q2YD73

Pathways: Regulation of Actin Filament Polymerization