ACVR1 antibody (N-Term)

Catalog No. ABIN2782109

This Rabbit Polyclonal antibody specifically detects ACVR1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Goat and Guinea Pig.

Quick Overview for ACVR1 antibody (N-Term) (ABIN2782109)

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ACVR1 Antibody

Binding Specificity: N-Term

Sequence: TCKTPPSPGQ AVECCQGDWC NRNITAQLPT KGKSFPGTQN FHLEVGLIIL

Predicted Reactivity: Cow: 100%, Dog: 93%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ACVR1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 509 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACVR1

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Alternative Name: ACVR1

Background: Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Alias Symbols: ACTRI, ACVRLK2, ALK2, FOP, SKR1, TSRI, ACVR1A
Protein Interaction Partner: UBC, USP15, BMPR1A, ACVR1, INHBA, ACVR2A, PEG10, SMAD6, SMAD7, BAMBI, SMURF1, IGSF1, TSC22D1, TGFBR1, DCAF6, FGD6, FCHO1, PLEK, TTC17, RHEBL1, WDR61, RASL12, RASD2, PLEKHJ1, CDK14, NEK8, DUSP13, NUAK2, FKBP4, RAB6B, RAB17, UBXN1, FBXO30, RHOJ, PLEKHB1, UB
Protein Size: 509

Molecular Weight: 55 kDa

Gene ID: 90

NCBI Accession: NM_001105, NP_001096

UniProt: Q04771