SEC63 antibody (N-Term)

Catalog No. ABIN2782761

Product Details anti-SEC63 Antibody

Target: SEC63 (SEC63 Homolog (SEC63))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC63 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: WPRDQNAEQI RLKNIRKVYG RCMWYRLRLL KPQPNIIPTV KKIVLLAGWA

Predicted Reactivity: Cow: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against SEC63. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SEC63

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 760 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SEC63 antibody (ABIN2782761)

You, Li, Kim, Kang, Koh, Chwae, Kim, Kim, Park, Jang, Kim: "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors." in: PLoS biology, Vol. 5, Issue 5, pp. e109, (2007) (PubMed).

Target Details for SEC63

Target: SEC63 (SEC63 Homolog (SEC63))

Alternative Name: SEC63 (SEC63 Products)

Background: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. SEC63 and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may
Alias Symbols: ERdj2, PRO2507, SEC63L, DNAJC23
Protein Interaction Partner: UBC, IRF1, SEC61B, SEC62, GSTK1,
Protein Size: 760

Molecular Weight: 88 kDa

Gene ID: 11231

NCBI Accession: NM_007214, NP_009145

UniProt: Q9UGP8

Pathways: ER-Nucleus Signaling