ALG1 antibody (N-Term)

Catalog No. ABIN2783751

Product Details anti-ALG1 Antibody

Target: ALG1 (Chitobiosyldiphosphodolichol beta-Mannosyltransferase (ALG1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALG1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VVLGDVGRSP RMQYHALSLA MHGFSVTLLG FCNSKPHDEL LQNNRIQIVG

Predicted Reactivity: Cow: 79%, Human: 100%, Mouse: 85%, Rabbit: 79%, Rat: 79%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against ALG1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ALG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 464 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ALG1

Target: ALG1 (Chitobiosyldiphosphodolichol beta-Mannosyltransferase (ALG1))

Alternative Name: ALG1 (ALG1 Products)

Synonyms: CDG1K antibody, HMAT1 antibody, HMT-1 antibody, HMT1 antibody, MT-1 antibody, Mat-1 antibody, hMat-1 antibody, zgc:66221 antibody, wu:fi34b12 antibody, alg1 antibody, hmat1 antibody, hmt1 antibody, ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase antibody, asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase) antibody, Beta-mannosyltransferase antibody, ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase L homeolog antibody, ALG1 antibody, Alg1 antibody, alg1 antibody, alg1.L antibody

Background: ALG1 catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. Defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K).The biosynthesis of lipid-linked oligosaccharides is highly conserved among eukaryotes and is catalyzed by 14 glycosyltransferases in an ordered stepwise manner. Mannosyltransferase I (MT I) catalyzes the first mannosylation step in this process.[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-421 BM767933.1 1-421 422-1179 AY359073.1 416-1173 1180-1444 CA455103.1 259-523 1445-1939 CD366777.1 17-511 c 1940-2122 BC031095.1 1931-2113 2123-2149 BQ002699.1 1-27 c
Alias Symbols: HMAT1, HMT-1, HMT1, MT-1, CDG1K, Mat-1, hMat-1
Protein Interaction Partner: UBC, FBXO6, BAG3, MMS19,
Protein Size: 464

Molecular Weight: 52 kDa

Gene ID: 56052

NCBI Accession: NM_019109, NP_061982

UniProt: Q9BT22