COL25A1 antibody (Middle Region)

Catalog No. ABIN2784040

Product Details anti-COL25A1 Antibody

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL25A1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GERGEAGPPG RGERGEPGAP GPKGKQGESG TRGPKGSKGD RGEKGDSGAQ

Predicted Reactivity: Cow: 85%, Dog: 100%, Guinea Pig: 80%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 85%, Rabbit: 86%, Rat: 93%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against COL25A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COL25A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 642 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COL25A1

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Alternative Name: COL25A1 (COL25A1 Products)

Synonyms: COL25A1 antibody, AMY antibody, CLAC antibody, CLAC-P antibody, CLACP antibody, 2700062B08Rik antibody, collagen type XXV alpha 1 chain antibody, collagen, type XXV, alpha 1 antibody, COL25A1 antibody, col25a1 antibody, Col25a1 antibody

Background: COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD) brains. COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD, MIM 104300) brains (Osada et al., 2005 [PubMed 15615705]).[supplied by OMIM].
Alias Symbols: CLAC, AMY, CLACP, CLAC-P
Protein Interaction Partner: COL25A1, APP, SNCA, IAPP,
Protein Size: 642

Molecular Weight: 64 kDa

Gene ID: 84570

NCBI Accession: NM_032518, NP_115907

UniProt: Q9BXS0