SENP6 antibody (C-Term)

Catalog No. ABIN2784244

Product Details anti-SENP6 Antibody

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Senp6. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1132 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Alternative Name: Senp6 (SENP6 Products)

Synonyms: SSP1 antibody, SUSP1 antibody, 2810017C20Rik antibody, E130319N12Rik antibody, Susp1 antibody, mKIAA0797 antibody, fc83h02 antibody, im:7148342 antibody, wu:fc83h02 antibody, zgc:171230 antibody, SUMO1/sentrin specific peptidase 6 antibody, SUMO/sentrin specific peptidase 6 antibody, SUMO1/sentrin specific peptidase 6a antibody, SENP6 antibody, Senp6 antibody, senp6a antibody

Background: Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797
Protein Interaction Partner: Sumo3, Ikbkg,
Protein Size: 1132

Molecular Weight: 127 kDa

Gene ID: 215351

NCBI Accession: NM_146003, NP_666115

UniProt: Q6P7W0