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FZR1 antibody (N-Term)

FZR1 Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784494
  • Target See all FZR1 Antibodies
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Binding Specificity
    • 15
    • 9
    • 8
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 56
    • 30
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse
    Host
    • 50
    • 6
    Rabbit
    Clonality
    • 50
    • 6
    Polyclonal
    Conjugate
    • 21
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FZR1 antibody is un-conjugated
    Application
    • 44
    • 23
    • 13
    • 13
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    SSPVSSPSKH GDRFIPSRAG ANWSVNFHRI NENEKSPSQN RKAKDATSDN
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against FZR1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1
    Top Product
    Discover our top product FZR1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 493 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hu, Li, Li, Tan, Wan, Zhu, Zhang, Zhang, Yao: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." in: Molecular pain, Vol. 12, (2016) (PubMed).

  • Target
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Alternative Name
    FZR1 (FZR1 Products)
    Synonyms
    CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
    Background
    FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
    Alias Symbols: CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
    Protein Interaction Partner: ZC3HC1, CDC25A, CCNB1, UBE2S, UBE2C, PTTG1, UBE2D2, TP53, CDR2, UBE2K, ANAPC4, PDS1, STAU1, CDK2, CDC27, RACGAP1, FOXM1, HECW2, PHF8, BTRC, CCNA1, UBC, SOX2, SKP2, PLK1, CUL1, CUEDC2, CDC20, kif22, SIRT2, CLSPN, ANAPC11, CDC14B, VHL, PTEN, EYA1, DAXX, BUB
    Protein Size: 493
    Molecular Weight
    55 kDa
    Gene ID
    51343
    NCBI Accession
    NM_016263, NP_057347
    UniProt
    Q9UM11
    Pathways
    DNA Replication, Synthesis of DNA
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