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Pseudouridylate Synthase 10 (PUS10) (Middle Region) antibody Primary Antibody

PUS10 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785075
$389.00
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100 μL
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  • Target
    Pseudouridylate Synthase 10 (PUS10)
    Binding Specificity
    Middle Region
    • 16
    • 9
    • 1
    • 1
    Reactivity
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish (Danio rerio)
    • 37
    • 20
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Host
    Rabbit
    • 37
    Clonality
    Polyclonal
    • 37
    Conjugate
    Un-conjugated
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Western Blotting (WB)
    • 25
    • 17
    • 13
    • 3
    • 3
    • 1
    Sequence
    AVFVAGRYNK YSRNLPQTPW IIDGERKLES SVEELISDHL LAVFKAESFN
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against CCDC139. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PUS10
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 529 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Pseudouridylate Synthase 10 (PUS10)
    Alternative Name
    PUS10 (PUS10 Antibody Abstract)
    Synonyms
    CCDC139, DOBI, 2810013G11Rik, 4933435A13Rik, AU014648, C77560, Ccdc139, RGD1306402, pseudouridylate synthase 10, PUS10, Pus10
    Background
    Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).
    Alias Symbols: FLJ32312, MGC126729, MGC126755, DOBI, CCDC139
    Protein Size: 529
    Molecular Weight
    60 kDa
    Gene ID
    150962
    NCBI Accession
    NM_144709, NP_653310
    UniProt
    Q3MIT2
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