ARG2 antibody (C-Term)

Catalog No. ABIN2785775

Product Details anti-ARG2 Antibody

Target: ARG2 (Arginase, Type II (ARG2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARG2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SALDLVEVNP QLATSEEEAK TTANLAVDVI ASSFGQTREG GHIVYDQLPT

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rabbit, Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 87%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ARG2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ARG2

Application Details

Application Notes: WB Suggested Anti-ARG2 Antibody Titration: 0.2-1 µg/mL
Positive Control: Jurkat cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 354 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ARG2 antibody (ABIN2785775)

Lukasova, Malaval, Gille, Kero, Offermanns: "Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells." in: The Journal of clinical investigation, Vol. 121, Issue 3, pp. 1163-73, (2011) (PubMed).

Target Details for ARG2

Target: ARG2 (Arginase, Type II (ARG2))

Alternative Name: Arginase-2 (ARG2 Products)

Synonyms: AII antibody, AU022422 antibody, zgc:65793 antibody, zgc:85630 antibody, wu:fb67g02 antibody, ARG2 antibody, LeARG2 antibody, arg1 antibody, arg3 antibody, arg2 antibody, arg2-c antibody, arg2-b antibody, arginase 2 antibody, arginase type II antibody, arginase 2 L homeolog antibody, arginase 2 S homeolog antibody, ARG2 antibody, Arg2 antibody, arg2 antibody, arg2.L antibody, arg2.S antibody

Background: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. ARG2 (type II isoform) is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood, it is thought to play a role in nitric oxide and polyamine metabolism.Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood, it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: UBC, ARG1,
Protein Size: 354

Molecular Weight: 39 kDa

Gene ID: 384

NCBI Accession: NM_001172, NP_001163

UniProt: P78540