PAD4 antibody (Middle Region)

Catalog No. ABIN2785937

Product Details anti-PAD4 Antibody

Target: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Rabbit, Sheep, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAD4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TGGISGLDSF GNLEVSPPVT VRGKEYPLGR ILFGDSCYPS NDSRQMHQAL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 87%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 86%, Rat: 100%, Sheep: 79%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PADI4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PADI4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 663 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PAD4 antibody (ABIN2785937)

Costenbader, Chang, De Vivo, Plenge, Karlson: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking." in: Arthritis research & therapy, Vol. 10, Issue 3, pp. R52, (2008) (PubMed).

Target Details for PAD4

Target: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Alternative Name: PADI4 (PADI4 Products)

Synonyms: PAD antibody, PAD4 antibody, PADI5 antibody, PDI4 antibody, PDI5 antibody, Pad4 antibody, Pdi4 antibody, peptidyl arginine deiminase 4 antibody, peptidyl arginine deiminase, type IV antibody, PADI4 antibody, Padi4 antibody

Background: PADI4 is an enzyme responsible for the conversion of arginine residues to citrulline residues. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PAD, PADI5, PDI4, PDI5, PAD4
Protein Interaction Partner: ANXA4, FBXO25, APP, ING4, ELK1, NPM1, TP53, HDAC2, HIST2H3A, HDAC1, TFF1, HIST4H4, HIST3H3,
Protein Size: 663

Molecular Weight: 74 kDa

Gene ID: 23569

NCBI Accession: NM_012387, NP_036519

UniProt: Q9UM07