SESN1 antibody (Middle Region)

Catalog No. ABIN2786032

Product Details anti-SESN1 Antibody

Target: SESN1 (Sestrin 1 (SESN1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SESN1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KWLNGLENAP QKLQNLGELN KVLAHRPWLI TKEHIEGLLK AEEHSWSLAE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against SESN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SESN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Alternative Name: SESN1 (SESN1 Products)

Synonyms: zgc:91970 antibody, sestrin-1 antibody, SESN1 antibody, XPA26 antibody, pa26 antibody, sest1 antibody, PA26 antibody, SEST1 antibody, 1110002G11Rik antibody, AU044290 antibody, Pa26 antibody, Sest1 antibody, sesn1-A antibody, sestrin 1 antibody, sestrin 1 L homeolog antibody, SESN1 antibody, sesn1 antibody, Sesn1 antibody, sesn1.L antibody

Background: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: PA26, SEST1
Protein Interaction Partner: UBC, RBX1, KEAP1, SQSTM1, PRDX1,
Protein Size: 551

Molecular Weight: 64 kDa

Gene ID: 27244

NCBI Accession: NM_014454, NP_055269