SMG5 antibody (N-Term)

Catalog No. ABIN2786101

Product Details anti-SMG5 Antibody

Target: SMG5 (Smg-5 Homolog, Nonsense Mediated mRNA Decay Factor (SMG5))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMG5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MSQGPPTGES SEPEAKVLHT KRLYRAVVEA VHRLDLILCN KTAYQEVFKP

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against SMG5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMG5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1016 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMG5

Target: SMG5 (Smg-5 Homolog, Nonsense Mediated mRNA Decay Factor (SMG5))

Alternative Name: SMG5 (SMG5 Products)

Synonyms: BC024683 antibody, mKIAA1089 antibody, EST1B antibody, LPTS-RP1 antibody, LPTSRP1 antibody, SMG-5 antibody, SMG5, nonsense mediated mRNA decay factor antibody, Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) antibody, SMG5 nonsense mediated mRNA decay factor antibody, SMG5 antibody, Smg5 antibody

Background: SMG5 plays a role in nonsense-mediated mRNA decay. SMG5 does not have RNase activity by itself. SMG5 promotes dephosphorylation of RENT1. SMG5 is necessary for TERT activity.SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM].
Alias Symbols: EST1B, FLJ34864, KIAA1089, LPTS-RP1, LPTSRP1, RP11-54H19.7, SMG-5
Protein Interaction Partner: RBM8A, UPF1, PHB, ZWINT, UBC, APP, HDAC8, STUB1, SMG7, SMG6, SMG1, TERT,
Protein Size: 1016

Molecular Weight: 114 kDa

Gene ID: 23381

NCBI Accession: NM_015327, NP_056142

UniProt: Q9UPR3