RALB antibody (Middle Region)

Catalog No. ABIN2786741

Product Details anti-RALB Antibody

Target: RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Goat, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RALB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EHESFTATAE FREQILRVKS EEDKIPLLVV GNKSDLEERR QVPVDEARGK

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Ralb. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Ralb

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 206 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RALB

Target: RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))

Alternative Name: Ralb (Ralb Products)

Synonyms: dRalb antibody, 5730472O18Rik antibody, Ral B antibody, ralb antibody, xralb antibody, zgc:100801 antibody, KRAS2 antibody, k-ras antibody, RAS like proto-oncogene B antibody, v-ral simian leukemia viral oncogene B antibody, v-ral simian leukemia viral oncogene homolog B L homeolog antibody, v-ral simian leukemia viral oncogene homolog Ba (ras related) antibody, v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) antibody, RALB antibody, Ralb antibody, ralb.L antibody, ralba antibody, ralb antibody

Background: Ralb is a multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Ralb accomplishes its multiple functions by interacting with distinct downstream effectors. It acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. It is required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Ralb plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. It is required for suppression of apoptosis.
Alias Symbols: 5730472O18Rik
Protein Interaction Partner: Rgl3,
Protein Size: 206

Molecular Weight: 23 kDa

Gene ID: 64143

NCBI Accession: NM_022327, NP_071722

UniProt: Q9JIW9

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events