SHC3 antibody (N-Term)

Catalog No. ABIN2786991

Product Details anti-SHC3 Antibody

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHC3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PSKMLSSILG KSNLQFAGMS ISLTISTASL NLRTPDSKQI IANHHMRSIS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against Shc3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 474 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SHC3

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Alternative Name: Shc3 (SHC3 Products)

Synonyms: N-Shc antibody, NSHC antibody, RAI antibody, SHCC antibody, ShcC antibody, Rai antibody, SHC adaptor protein 3 antibody, src homology 2 domain-containing transforming protein C3 antibody, SHC3 antibody, Shc3 antibody

Background: Shc3 is a signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. It is involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Alias Symbols: MGC124163, N-Shc, Rai, ShcC
Protein Interaction Partner: Src, Grin2b, Grin1, Axl, Egfr, Ntrk1,
Protein Size: 474

Molecular Weight: 52 kDa

Gene ID: 20418

NCBI Accession: NM_009167, NP_033193

UniProt: Q61120

Pathways: RTK Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway