GNB4 antibody (Middle Region)

Catalog No. ABIN2787271

Product Details anti-GNB4 Antibody

Target: GNB4 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 4 (GNB4))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNB4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DGMCRQSFTG HVSDINAVSF FPNGYAFATG SDDATCRLFD LRADQELLLY

Specificity: Gene Symbol: GNB1, GNB2, GNB3
Protein Accession#: NP_002065, NP_005264, NP_002066
Nucleotide Accession#: NM_002074, NM_005273, NM_002075
Swissprot ID: P62873, P62879, P16520

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against all four GNB variants (1-4). It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GNB4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 340 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GNB4

Target: GNB4 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 4 (GNB4))

Alternative Name: GNB4 (GNB4 Products)

Synonyms: 6720453A21Rik antibody, G(beta)4 antibody, CMTD1F antibody, guanine nucleotide binding protein (G protein), beta 4 antibody, G protein subunit beta 4 antibody, Gnb4 antibody, GNB4 antibody

Background: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.
Alias Symbols: -
Protein Interaction Partner: UBC, SUMO2, GNG8, GNG12, GNG2, GNG13, GNGT1, GNG11, GNG10, GNG7, GNG5, GNG4, GNG3, FBXO6, CDK18, ADRB2, PAN2, MTNR1A, ESR1, GNAI3, GNAI2, GNAI1, PDCL, CEP97, RGS6, Haus1, Haus4, Mau2, Trim69, Cdk1, MTNR1B, GNGT2, git11,
Protein Size: 340

Molecular Weight: 37 kDa

Gene ID: 59345

NCBI Accession: NM_021629, NP_067642

UniProt: Q9HAV0

Pathways: Myometrial Relaxation and Contraction