GTF2I antibody (Middle Region)

Catalog No. ABIN2787508

Product Details anti-GTF2I Antibody

Target: GTF2I (General Transcription Factor III (GTF2I))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF2I antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: INNQLVDQSE SEGPVIQESA EPSQLEVPAT EEIKETDGSS QIKQEPDPTW

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GTF2I. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GTF2I

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 998 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-GTF2I antibody (ABIN2787508)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Target Details for GTF2I

Target: GTF2I (General Transcription Factor III (GTF2I))

Alternative Name: GTF2I (GTF2I Products)

Synonyms: BAP135 antibody, BTKAP1 antibody, DIWS antibody, GTFII-I antibody, IB291 antibody, SPIN antibody, TFII-I antibody, WBS antibody, WBSCR6 antibody, Gtf2ird1 antibody, 6030441I21Rik antibody, BAP-135 antibody, GtfII-I antibody, Spin antibody, bap-135 antibody, bap135 antibody, btkap1 antibody, diws antibody, gtfii-i antibody, ib291 antibody, spin antibody, tfii-i antibody, wbs antibody, wbscr6 antibody, gtf2i antibody, gtf2i.L antibody, general transcription factor IIi antibody, general transcription factor II I antibody, general transcription factor IIi S homeolog antibody, GTF2I antibody, Gtf2i antibody, gtf2i antibody, gtf2i.S antibody

Background: GTF2I is a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants. This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Four transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: BAP-135, BAP135, BTKAP1, DIWS, IB291, SPIN, TFII-I, WBS, WBSCR6, GTFII-I
Protein Interaction Partner: TP53, ZMYM3, PIAS2, TUBG1, TRAF6, SUMO2, SUMO3, AP2B1, DPY30, GCC1, MTUS2, MDM2, UBC, SUMO1, RPA3, RPA2, RPA1, EED, RNF2, SUZ12, CTPS2, WARS, RPL28, RAD23B, PRPS2, PRKDC, NUCB1, METTL1, ADSL, FBXO6, UBD, CBX2, TAB2, AP4S1, CBX4, MAPK12, C4BPA, MAP3K3, SLU
Protein Size: 998

Molecular Weight: 112 kDa

Gene ID: 2969

NCBI Accession: NM_032999, NP_127492

UniProt: P78347