TRPC3 antibody (N-Term)

Catalog No. ABIN2787800

Product Details anti-TRPC3 Antibody

Target: TRPC3 (Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPC3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MEGSPSLRRM TVMREKGRRQ AVRGPAFMFN DRGTSLTAEE ERFLDAAEYG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against TRPC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of human TRPC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 848 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRPC3

Target: TRPC3 (Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3))

Alternative Name: TRPC3 (TRPC3 Products)

Synonyms: TRPC3 antibody, Trpc3 antibody, TRP3 antibody, Mwk antibody, Trcp3 antibody, Trp3 antibody, Trrp3 antibody, TrpC3c antibody, transient receptor potential cation channel subfamily C member 3 antibody, transient receptor potential cation channel, subfamily C, member 3 antibody, TRPC3 antibody, Trpc3 antibody

Background: TRPC3 is thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC3 is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. TRPC3 may also be activated by internal calcium store depletion.
Alias Symbols: TRP3
Protein Interaction Partner: STX3, TRPC1, PRKG1, ORAI1, PLCB1, PLCB2, TRPC6, NAPA, PLCB3, FKBP1A, VAMP2, SLC8A1, PRKCA, PLCG1, ITPR3, ITPR1, MX1, GNA11, CALM1, TRPC7, TRPC3, TRPC5, TRPC4,
Protein Size: 848

Molecular Weight: 97 kDa

Gene ID: 7222

NCBI Accession: NM_003305, NP_003296

UniProt: Q13507