TMED10 antibody (Middle Region)

Catalog No. ABIN2787806

Product Details anti-TMED10 Antibody

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Zebrafish (Danio rerio), Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMED10 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KLKPLEVELR RLEDLSESIV NDFAYMKKRE EEMRDTNEST NTRVLYFSIF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TMED10. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMED10

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 219 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TMED10

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Alternative Name: TMED10 (TMED10 Products)

Synonyms: tmp21 antibody, P24(DELTA) antibody, S31I125 antibody, S31III125 antibody, TMP21 antibody, Tmp-21-I antibody, p23 antibody, 1110014C03Rik antibody, Tmp21 antibody, p24delta1 antibody, fe06g04 antibody, wu:fb98e10 antibody, wu:fe06g04 antibody, zgc:85681 antibody, transmembrane p24 trafficking protein 10 L homeolog antibody, transmembrane p24 trafficking protein 10 antibody, tmed10.L antibody, TMED10 antibody, Tmed10 antibody, tmed10 antibody

Background: TMED10 is involved in vesicular protein trafficking.This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Alias Symbols: P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23
Protein Interaction Partner: UBC, SUMO1, NEDD8, ASB8, RNF2, FBXO6, rev, TMED9, COPZ1, SEC23B, UBL4A, DHODH, ATF2, VCP, PTRF, S100A16, NIT2, PRDX6, SEC22B, EIF3C, VAMP2, COPG1, COPE, COPB2, COPB1, COPA, ARCN1, CDK2, EBNA-LP, RYK, TMED2, PSENEN, APH1A, NCSTN, ARF1, GORASP2,
Protein Size: 219

Molecular Weight: 24 kDa

Gene ID: 10972

NCBI Accession: NM_006827, NP_006818

UniProt: P49755