MRGPRX2 antibody (Middle Region)

Catalog No. ABIN2788260

Product Details anti-MRGPRX2 Antibody

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRX2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VCVLLWALSL LLSILEGKFC GFLFSDGDSG WCQTFDFITA AWLIFLFMVL

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against MRGPRX2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MRGPRX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 330 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MRGPRX2

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Alternative Name: MRGPRX2 (MRGPRX2 Products)

Synonyms: MRGX2 antibody, G370024M05Rik antibody, MrgB10 antibody, Mrgprb10 antibody, MrgB1 antibody, Mrgprb1 antibody, MAS related GPR family member X2 antibody, MAS-related GPR, member X2 antibody, MRGPRX2 antibody, Mrgprx2 antibody

Background: MRGPRX2 is an orphan receptor. It probably involved in the function of nociceptive neurons. It also may regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca2+ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Alias Symbols: MRGX2
Protein Interaction Partner: CORT,
Protein Size: 330

Molecular Weight: 37 kDa

Gene ID: 117194

NCBI Accession: NM_054030, NP_473371

UniProt: Q96LB1