IL4 Receptor antibody (C-Term)

Catalog No. ABIN2788560

Product Details anti-IL4 Receptor Antibody

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL4 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GLDREPPRSP QSSHLPSSSP EHLGLEPGEK VEDMPKPPLP QEQATDPLVD

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against IL4R. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IL4R

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Alternative Name: IL4R (IL4R Products)

Synonyms: IL4R antibody, il-4ra antibody, zgc:113063 antibody, CD124 antibody, IL-4RA antibody, IL4RA antibody, Il4ra antibody, IL4 antibody, Il4r antibody, interleukin 4 receptor antibody, interleukin 4 receptor, tandem duplicate 1 antibody, interleukin 4 receptor, alpha antibody, IL4R antibody, il4r.1 antibody, Il4r antibody, Il4ra antibody

Background: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Protein Interaction Partner: UBC, JAK3, CD40, STAT6, JAK2, JAK1, IL2RG, SOCS5, KAT5, HGS, ARIH2, INPP5D, DOK2, IRS2, SHC1, IL13RA1, NCF1, FES, PRKCZ, GNB2L1, PTPN6, PTPN11, IL4, IL13, IRS1,
Protein Size: 825

Molecular Weight: 87 kDa

Gene ID: 3566

UniProt: P24394

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process