HVEM antibody (Middle Region)

Catalog No. ABIN2788790

Product Details anti-HVEM Antibody

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HVEM antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VCGCSPGHFC IVQDGDHCAA CRAYATSSPG QRVQKGGTES QDTLCQNCPP

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against TNFRSF14. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 283 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HVEM

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Alternative Name: TNFRSF14 (TNFRSF14 Products)

Synonyms: ATAR antibody, CD270 antibody, HVEA antibody, HVEM antibody, LIGHTR antibody, TR2 antibody, Atar antibody, HveA antibody, Hvem antibody, Tnfrs14 antibody, TNF receptor superfamily member 14 antibody, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) antibody, Tnfrsf14 antibody, TNFRSF14 antibody

Target Type: Viral Protein

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.
Alias Symbols: ATAR, HVEA, HVEM, LIGHTR, TR2, CD270
Protein Interaction Partner: BTLA, CD160, APP, RAD21, WDR73, ITFG1, KIAA1377, UBQLN4, DRAP1, MBTPS1, DYNLL1, DGKD, SERPINA4, NDUFS2, IMPA2, ZBTB48, A2M, CHD3, HDAC3, HDAC4, TNFSF14, TNFSF13, TNFRSF14, NRIP1, TRAF5, TRAF3, TRAF2, TRAF1, VIM, LTA, ESR1, UGGT1, SEC11A, GCN1L1, PDIA6, P4
Protein Size: 283

Molecular Weight: 31 kDa

Gene ID: 8764

NCBI Accession: NM_003820, NP_003811

UniProt: Q92956

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints