PRKAR2A antibody (Middle Region)
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- Target See all PRKAR2A Antibodies
- PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Rat, Mouse, Pig, Dog, Cow, Horse, Rabbit, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRKAR2A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- DILVTKDNQT RSVGQYDNRG SFGELALMYN TPRAATIVAT SEGSLWGLDR
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against PRKAR2A. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product PRKAR2A Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 404 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
- Alternative Name
- PRKAR2A (PRKAR2A Products)
- Synonyms
- PKR2 antibody, PRKAR2 antibody, prkar2a antibody, zgc:85886 antibody, PRKAR2A antibody, 1110061A24Rik antibody, AI317181 antibody, AI836829 antibody, RII(alpha) antibody, protein kinase cAMP-dependent type II regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha, B antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha antibody, protein kinase, cAMP dependent regulatory, type II alpha antibody, protein kinase cAMP-dependent type 2 regulatory subunit alpha antibody, PRKAR2A antibody, prkar2ab antibody, Prkar2a antibody
- Background
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CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
Alias Symbols: MGC3606, PKR2, PRKAR2
Protein Interaction Partner: UBC, SUZ12, IMPDH2, GPS1, CSRP1, KPNA6, PRKACB, PRKACA, GCH1, WASF1, VCP, CIRBP, ELAVL1, PJA2, Dynll1, AKAP7, PPP1CB, MYCBPAP, ARFGEF2, AKAP2, RAB32, NBEA, AKAP12, AKAP11, AKAP10, AKAP8, AKAP6, AKAP3, AKAP5, AKAP13, AKAP9, CBFA2T3, SMAD3, AKAP1, CFTR, SMA
Protein Size: 404 - Molecular Weight
- 44 kDa
- Gene ID
- 5576
- NCBI Accession
- NM_004157, NP_004148
- UniProt
- P13861
- Pathways
- Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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