PFKFB1 antibody (C-Term)

Catalog No. ABIN2788934

Product Details anti-PFKFB1 Antibody

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio), Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKFB1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EEMTYEEIQE HYPEEFALRD QDKYRYRYPK GESYEDLVQR LEPVIMELER

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PFKFB1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 471 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PFKFB1

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Alternative Name: PFKFB1 (PFKFB1 Products)

Synonyms: zgc:55328 antibody, wu:fi11h10 antibody, PFKFB1 antibody, F6PK antibody, HL2K antibody, PFRX antibody, Pfkfb01 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 S homeolog antibody, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 antibody, pfkfb1 antibody, PFKFB1 antibody, pfkfb1.S antibody, LOC100475853 antibody, Pfkfb1 antibody

Background: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.
Alias Symbols: F6PK, HL2K, MGC116715, MGC116717, PFRX
Protein Interaction Partner: PFKFB1, Prkaa2, PRKCA, PRKACA, APP, AKT1, MAPK3,
Protein Size: 471

Molecular Weight: 54 kDa

Gene ID: 5207

NCBI Accession: NM_002625, NP_002616

UniProt: P16118

Pathways: Regulation of Carbohydrate Metabolic Process