MASP1 antibody (N-Term)

Catalog No. ABIN2789651

Product Details anti-MASP1 Antibody

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MASP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PGSFMSITFR SDFSNEERFT GFDAHYMAVD VDECKEREDE ELSCDHYCHN

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MASP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MASP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 699 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MASP1

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Alternative Name: MASP1 (MASP1 Products)

Synonyms: AW048060 antibody, CCPII antibody, Crarf antibody, Masp1/3 antibody, 3MC1 antibody, CRARF antibody, CRARF1 antibody, MAP1 antibody, MASP antibody, MASP3 antibody, MAp44 antibody, PRSS5 antibody, RaRF antibody, mannan-binding lectin serine peptidase 1 antibody, mannan binding lectin serine peptidase 1 antibody, Masp1 antibody, MASP1 antibody

Background: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway.
Alias Symbols: CRARF, CRARF1, DKFZp686I01199, FLJ26383, MASP, MGC126283, MGC126284, PRSS5, RaRF
Protein Interaction Partner: CDK19, CUL3, PDCD6IP, RPS6KA6, MAPK8IP2, NUDT21, NCK2, UFD1L, RPS6KA3, MAPK6, H2AFX, GSK3B, GADD45A, C2, SERPING1, FCN2, MBL2, C3, MASP2,
Protein Size: 699

Molecular Weight: 28 kDa

Gene ID: 5648

NCBI Accession: NM_001879, NP_001870

UniProt: P48740

Pathways: Complement System