SNTA1 antibody (N-Term)

Catalog No. ABIN2790311

Product Details anti-SNTA1 Antibody

Target: SNTA1 (Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNTA1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SPGPTPRNFS EAKHMSLKMA YVSKRCTPND PEPRYLEICS ADGQDTLFLR

Predicted Reactivity: Cow: 79%, Guinea Pig: 86%, Horse: 82%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against SNTA1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human SNTA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SNTA1

Target: SNTA1 (Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1))

Alternative Name: SNTA1 (SNTA1 Products)

Synonyms: SNTA1 antibody, MGC147484 antibody, AW228934 antibody, Snt1 antibody, LQT12 antibody, SNT1 antibody, TACIP1 antibody, dJ1187J4.5 antibody, syntrophin alpha 1 antibody, syntrophin, alpha 1 L homeolog antibody, syntrophin, alpha 1 antibody, syntrophin, acidic 1 antibody, SNTA1 antibody, snta1.L antibody, snta1 antibody, Snta1 antibody

Background: Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
Alias Symbols: SNT1, LQT12, TACIP1, dJ1187J4.5
Protein Size: 396

Molecular Weight: 43 kDa

Gene ID: 6640

NCBI Accession: NM_003098, NP_003089

UniProt: Q13424

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development